Institut für Pharmakologie und Toxikologie der Technischen Universität München, Biedersteiner Str. 29, 8000 München 40, Germany.
Trends Cardiovasc Med. 1993 Mar-Apr;3(2):48-53. doi: 10.1016/1050-1738(93)90036-6.
The high-voltage-activated calcium channel is a multimeric protein complex containing α(1), α(2)/δ, β, and γ subunits. The α(1) subunit is the ion conduction channel and contains the binding sites for calcium channel blockers and toxins. Three genes code for distinct L-type, dihydropyridine-sensitive α(1) subunits; one gene codes for the neuronal P-type (Purkinje) α(1) subunit; and one gene codes for the neuronal N-type α(1) subunit. The smooth and cardiac muscle L-type calcium channel α(1) subunits are splice variants of the same gene. The α(1) subunits are coexpressed with a common α(2)/δ subunit and tissue-specific β subunits (at least three genes). The γ subunit apparently is expressed only in skeletal muscle. The properties of these cloned and expressed calcium channels are discussed here.
高电压激活钙通道是一种包含α(1)、α(2)/δ、β和γ亚基的多聚体蛋白复合物。α(1)亚基是离子传导通道，包含钙通道阻滞剂和毒素的结合位点。三个基因编码不同的 L 型、二氢吡啶敏感的α(1)亚基；一个基因编码神经元 P 型（浦肯野）α(1)亚基；一个基因编码神经元 N 型α(1)亚基。平滑肌和心肌 L 型钙通道α(1)亚基是同一基因的剪接变异体。α(1)亚基与共同的α(2)/δ亚基和组织特异性β亚基（至少三个基因）共同表达。γ亚基显然仅在骨骼肌中表达。这里讨论了这些克隆和表达的钙通道的特性。
