Nakayama H
Faculty of Pharmaceutical Sciences, Hokkaido University.
Nihon Rinsho. 1993 Jun;51(6):1471-6.
Voltage gated L-type and T-type calcium channels are electrophysiologically characterized in the cardiac tissues. L-Type calcium channels are abundant in skeletal muscle and results from molecular studies have stimulated researches on the cardiac counterpart. This paper briefly reviews the recent progress in molecular constituents and functional sites of the cardiac calcium channel. The channel is composed of five subunits, alpha 1, alpha 2, beta, gamma, and delta, at least, but heterogeneous existence of alpha 1, beta, and gamma is also observed. The 1,4-dihydropyridine binding site has been identified in the skeletal muscle and cardiac calcium channels by photoaffinity labeling. Their sites are compared in the primary structures. PKA modulation of the cardiac channel is also discussed with the respect to phosphorylation site.
电压门控L型和T型钙通道在心脏组织中具有电生理特征。L型钙通道在骨骼肌中含量丰富，分子研究结果激发了对心脏对应物的研究。本文简要综述了心脏钙通道分子组成和功能位点的最新进展。该通道至少由五个亚基组成，即α1、α2、β、γ和δ，但也观察到α1、β和γ的异质性存在。通过光亲和标记已在骨骼肌和心脏钙通道中鉴定出1,4 - 二氢吡啶结合位点。在一级结构中对它们的位点进行了比较。还从磷酸化位点的角度讨论了蛋白激酶A对心脏通道的调节。
