Wang Meng-Fei, Xue Cong, Shi Shun-Yi, Yang Ling, Zhu Zhen-Yan, Li Jian-Jun
Department of Cardiology, The Third Affiliated Hospital of Soochow University, The First People's Hospital of Changzhou, 213000 Changzhou, Jiangsu, China.
State Key Laboratory of Cardiovascular Diseases, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 100037 Beijing, China.
Rev Cardiovasc Med. 2023 Apr 18;24(4):119. doi: 10.31083/j.rcm2404119. eCollection 2023 Apr.
Atrial fibrillation (AF) is one of the most common cardiac arrhythmias, but its pathogenesis is still poorly understood. Catheter ablation is one of the most effective treatments for AF, but recurrence after ablation remains a challenge. There has been much research into the association of AF recurrence with several factors, including genetics. Over the past decade or so, significant advances have been made in the genetic architecture of atrial fibrillation. Genome-wide association studies (GWAS) have identified over 100 loci for genetic variants associated with atrial fibrillation. However, there is relatively little information on the systematic assessment of the genes related to AF recurrence after ablation. In this review article, we highlight the value of genetic polymorphisms in atrial fibrillation recurrence after catheter ablation and their potential mechanisms in the recurrence process to enhance our understanding of atrial fibrillation recurrence and contribute to individualized treatment strategies for patients with AF.
心房颤动（AF）是最常见的心律失常之一，但其发病机制仍未完全明确。导管消融是治疗AF最有效的方法之一，但消融后复发仍是一个挑战。关于AF复发与多种因素包括遗传学的关联，已有很多研究。在过去十年左右的时间里，心房颤动的遗传结构取得了重大进展。全基因组关联研究（GWAS）已经确定了100多个与心房颤动相关的基因变异位点。然而，关于消融后与AF复发相关基因的系统评估信息相对较少。在这篇综述文章中，我们强调了基因多态性在导管消融后心房颤动复发中的价值及其在复发过程中的潜在机制，以增进我们对心房颤动复发的理解，并为AF患者的个体化治疗策略做出贡献。
