Lunel-Fabiani F, Guivarch P, Valla D, Grippon P, Marques M A, Huraux J M, Le Charpentier Y, Levy V G, Bousquet O, Opolon P
Service d'Hépato-Gastroentérologie, Hôpital de la Pitié-Salpêtrière, Paris.
Gastroenterol Clin Biol. 1990;14(10):705-9.
The type and predicting factors of response to alpha interferon therapy have been studied in 26 patients with chronic non-A non-B hepatitis. Interferon was administered three times weekly during 6 months at a dose of 3 millions units/day. Eleven patients (42 percent) had serum alanine aminotransferase levels below 1.5 times the upper limit of normal range at the end of treatment. Only eight (31 percent) patients had persistent normalization of seric alanine aminotransferase value, 6 months after the end of the interferon treatment. The main factors involved in the response to therapy were age, apparent duration of the disease, and mode of contamination: patients who responded to interferon were younger, had a shorter duration of hepatitis and a parenterally transmitted disease.
对26例慢性非甲非乙型肝炎患者进行了α干扰素治疗反应的类型及预测因素研究。干扰素每周给药3次，共6个月，剂量为每日300万单位。11例患者（42%）在治疗结束时血清丙氨酸氨基转移酶水平低于正常范围上限的1.5倍。仅8例（31%）患者在干扰素治疗结束6个月后血清丙氨酸氨基转移酶值持续正常。治疗反应的主要相关因素为年龄、疾病的明显持续时间及感染方式：对干扰素治疗有反应的患者年龄较轻、肝炎病程较短且为经肠外传播的疾病。
