Romanova G A, Shakova F M, Gorbatov V Yu, Kvashennikova Yu N, Davydova T V
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Bull Exp Biol Med. 2010 Sep;149(3):289-92. doi: 10.1007/s10517-010-0929-9.
Experiments were performed on rats with bilateral photothrombosis of vessels in the prefrontal cortex. Intranasal administration of antibodies to glutamate (1 h after ischemia of the brain cortex) improved retention of conditioned passive avoidance response, which was elicited before ischemic damage. The content of antibodies to glutamate in the serum of rats increased significantly on day 8 after bilateral photochemical thrombosis of vessels in the prefrontal cortex compared to that in the control.
对前额叶皮质血管进行双侧光血栓形成的大鼠进行了实验。在脑皮质缺血1小时后经鼻给予谷氨酸抗体，改善了缺血损伤前诱发的条件性被动回避反应的保持。与对照组相比，前额叶皮质血管双侧光化学血栓形成后第8天，大鼠血清中谷氨酸抗体含量显著增加。
