谷氨酸抗体对前额叶皮质缺血性损伤大鼠脑结构中神经递质氨基酸含量的影响。
Effect of antibodies to glutamate on the content of neurotransmitter amino acids in brain structures of rats with ischemic damage to the prefrontal cortex.
作者信息
Romanova G A, Kvashennikova Yu N, Shakova F M, Davydova T V
机构信息
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2012 May;153(1):13-5. doi: 10.1007/s10517-012-1631-x.
PMID:22808482
Abstract
Experiments on the model of bilateral photothrombosis in the prefrontal cortex showed that antibodies to glutamate administered intranasally 1 h after ischemic damage to the brain cortex led to a decrease in glutamate content in the hippocampus and prefrontal cortex and had no effect on aspartate concentration in these structures of the brain.
摘要
在前额叶皮质双侧光血栓形成模型上进行的实验表明，在大脑皮质缺血损伤后1小时经鼻给予谷氨酸抗体，可使海马体和前额叶皮质中的谷氨酸含量降低，且对这些脑结构中的天冬氨酸浓度没有影响。
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