老年人往往缺乏对破伤风的免疫力。
[Immunity against tetanus is often lacking in the elderly].
作者信息
Hof H, Bartel J
机构信息
Labor Limbach, Im Breitspiel 15, 69126 Heidelberg.
出版信息
Dtsch Med Wochenschr. 2011 Jan;136(4):148-50. doi: 10.1055/s-0031-1272499. Epub 2011 Jan 18.
BACKGROUND AND OBJECTIVE
It is generally recommended to vaccinate elderly people against tetanus. Is this really essential?
PATIENTS AND METHODS
The levels of antibodies to tetanus toxin in serum of 2936 individuals of various age groups were determined by means of an ELISA.
RESULTS
Obviously, the antibody titers definitely diminish in the old individuals. About 50 % of people > 80 years possess antibody titers < 0.5 IU/ml and about 30 % antibody titers < 0.1 IU/ml, which means that they are not absolutely protected against tetanus.
CONCLUSION
This, however is not due to a general decline of antibodies, since levels of immunoglobulins of the classes IgG, IgM and especially of IgA are higher with growing age.It can be assumed that the awareness for the necessity for vaccination is lacking.
背景与目的
通常建议老年人接种破伤风疫苗。这真的有必要吗？
患者与方法
采用酶联免疫吸附测定法（ELISA）测定了2936名不同年龄组个体血清中破伤风毒素抗体水平。
结果
显然，老年人的抗体滴度明显降低。80岁以上人群中约50%的抗体滴度<0.5 IU/ml，约30%的抗体滴度<0.1 IU/ml，这意味着他们并未得到完全的破伤风免疫保护。
结论
然而，这并非由于抗体普遍下降，因为随着年龄增长，IgG、IgM尤其是IgA类免疫球蛋白水平会升高。可以推测，人们缺乏对疫苗接种必要性的认识。
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