应用吲哚菁绿实时荧光导航行前哨淋巴结活检术在头颈部/唇部皮肤黏膜黑色素瘤中的应用。
Sentinel lymph node biopsy using real-time fluorescence navigation with indocyanine green in cutaneous head and neck/lip mucosa melanomas.
机构信息
Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
出版信息
Head Neck. 2012 May;34(5):758-61. doi: 10.1002/hed.21651. Epub 2011 Jan 18.
BACKGROUND
The triple technique (lymphoscintigraphy, patent-blue staining, and a gamma probe) constitutes a reliable method for the sentinel lymph node (SLN) biopsy. However, in head and neck melanomas, a shine-through phenomenon, which occurs because these SLNs are close to the primary focus, is irreversibly problematic. To get around the shine-through phenomenon, this study uses the fluorescence navigation with indocyanine green (ICG) as well as the triple technique.
METHODS
ICG is a green dye and can be used as a marker with infrared fluorescence. ICG solution is intradermally injected around the tumor. By using Photodynamic Eye (PDE) intraoperatively, it is possible to observe the injected ICG as SLNs in the fluorescence images.
RESULTS
By use of the fluorescence imaging with ICG, clear identification of the SLN of the case became possible.
CONCLUSIONS
We think the fluorescence navigation with ICG will be a useful option for the SLN biopsy in head and neck melanomas.
背景
三联合技术（淋巴闪烁显像术、专利蓝染色和伽马探针）是前哨淋巴结（SLN）活检的可靠方法。然而，在头颈部黑色素瘤中，由于这些 SLN 靠近原发灶，会出现一种不可逆转的“透光现象”。为了解决透光现象，本研究使用吲哚菁绿（ICG）荧光导航和三联合技术。
方法
ICG 是一种绿色染料，可用作具有红外荧光的标记物。将 ICG 溶液皮内注射到肿瘤周围。术中使用光动力眼（PDE），可以在荧光图像中观察到注射的 ICG 作为 SLN。
结果
通过使用 ICG 荧光成像，能够清晰地识别病例的 SLN。
结论
我们认为，ICG 荧光导航将是头颈部黑色素瘤 SLN 活检的一种有用选择。
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