Génomique et Physiologie de la Lactation, INRA, UR1196, Jouy-en-Josas, France.
Dev Dyn. 2011 Feb;240(2):347-56. doi: 10.1002/dvdy.22536. Epub 2011 Jan 11.
Alterations to the metabolic environment during puberty can impact future lactation efficiency and mammary tumorigenesis. During this study, we used a model of rabbits receiving an obesogenic diet (OD), starting before puberty and extending until mid-pregnancy. Three months later, the body weight of OD animals was significantly higher than that of controls and their mammary glands displayed a precocious and abnormal development at mid-pregnancy. OD mammary ducts were filled with dense products, while alveolar structures invaded most of the fat pad. The proportion of secretory epithelium was significantly higher in OD mammary tissue, which contained an abundant accumulation of milk proteins and lipids. In conclusion, an obesogenic diet started before puberty induced an accelerated development of the rabbit mammary gland, leading to an accumulation of secretory products at mid-pregnancy. These results support the critical influence of nutrition on mammary growth and differentiation, which may be deleterious to mammary development and subsequent lactation.
青春期代谢环境的改变会影响未来的泌乳效率和乳腺肿瘤发生。在这项研究中，我们使用了一种在青春期前开始并持续到妊娠中期的致肥胖饮食（OD）的兔子模型。三个月后，OD 动物的体重明显高于对照组，其乳腺在妊娠中期表现出早熟和异常发育。OD 乳腺导管充满密集产物，而肺泡结构侵入大部分脂肪垫。OD 乳腺组织中的分泌上皮比例明显更高，其中含有丰富的乳蛋白和脂质积累。总之，青春期前开始的致肥胖饮食诱导兔子乳腺加速发育，导致妊娠中期分泌产物的积累。这些结果支持营养对乳腺生长和分化的关键影响，这可能对乳腺发育和随后的泌乳有害。
