反向疫苗接种以沉默多发性硬化症中的髓鞘免疫。

Inverse vaccination to silence immunity to myelin in multiple sclerosis.

机构信息

Department of Neurological Sciences and Interdepartmental Program in Immunology, Stanford University, Stanford, California, 94305, USA.

出版信息

Can J Neurol Sci. 2010 Sep;37 Suppl 2:S49-58. doi: 10.1017/s0317167100022435.

DOI:10.1017/s0317167100022435

PMID:21246935

Abstract

The adaptive immune response in multiple sclerosis is complex. We have devised large scale arrays to measure the antibody response to myelin proteins and lipids. Despite the widespread immune responses to myelin, we have devised an inverse vaccine aimed at turning off key drivers of this diverse response. Clinical trials in patients with multiple sclerosis show that it is possible to constrain antibody responses to myelin on a large scale with this approach.

摘要

多发性硬化症中的适应性免疫反应很复杂。我们设计了大规模的阵列来测量针对髓鞘蛋白和脂质的抗体反应。尽管对髓鞘存在广泛的免疫反应，但我们设计了一种反向疫苗，旨在关闭这种多样化反应的关键驱动因素。多发性硬化症患者的临床试验表明，通过这种方法大规模限制针对髓鞘的抗体反应是可能的。