Ainsworth M A, Kjeldsen J, Schaffalitzky de Muckadell O B
Dept. of Medical Gastroenterology S, Odense University Hospital, Denmark.
Scand J Gastroenterol. 1990 Oct;25(10):1066-75. doi: 10.3109/00365529008997636.
Mucus and bicarbonate secreted from the epithelium are thought to be important for the protection of the duodenal mucosa against acid and pepsin, but so far little is known about the regulation of human duodenal mucosal bicarbonate secretion. After isolating a segment of the proximal human duodenum from gastric and pancreaticobiliary secretion we quantified the secretion of bicarbonate from the human duodenal mucosa. The method was evaluated by measurements of basal and prostaglandin E1 analogue-stimulated bicarbonate secretion. The duodenal mucosal bicarbonate secretion was inhibited 70% after intravenous infusion of morphine in a dose of 73.6 micrograms/kg/h and increased after intravenous administration of naloxone. Thus, the inhibition is most likely mediated by mu-receptors, and the results suggest a role of endogenous opioids in the regulation of the secretion of bicarbonate from the human duodenal mucosa.
上皮细胞分泌的黏液和碳酸氢盐被认为对保护十二指肠黏膜免受酸和胃蛋白酶的侵害很重要，但迄今为止，关于人类十二指肠黏膜碳酸氢盐分泌的调节知之甚少。在将一段人类十二指肠近端与胃和胰胆管分泌隔离开后，我们对人类十二指肠黏膜的碳酸氢盐分泌进行了定量。该方法通过测量基础和前列腺素E1类似物刺激的碳酸氢盐分泌来评估。静脉注射剂量为73.6微克/千克/小时的吗啡后，十二指肠黏膜碳酸氢盐分泌受到70%的抑制，而静脉注射纳洛酮后则增加。因此，这种抑制很可能是由μ受体介导的，结果表明内源性阿片类物质在调节人类十二指肠黏膜碳酸氢盐分泌中起作用。
