抗Rh(D) IgG亚类与新生儿Rh溶血病的严重程度。

Anti-Rh(D) IgG subclasses and severity of Rh hemolytic disease of the newborn.

作者信息

Pollock J M, Bowman J M

机构信息

Rh Laboratory, Health Sciences Centre, University of Manitoba, Winnipeg, Canada.

出版信息

Vox Sang. 1990;59(3):176-9. doi: 10.1111/j.1423-0410.1990.tb00854.x.

DOI:10.1111/j.1423-0410.1990.tb00854.x

PMID:2124753

Abstract

The influence of anti-Rh(D) IgG subclasses on the severity of hemolytic disease of the newborn was examined in 98 pregnancies. Disease was severe in 19 of 32 cases in which only IgG1 was detected, 40 of 63 cases in which IgG1 and IgG3 were found and 0 of 3 cases in which only IgG3 was detected. When both IgG1 and IgG3 anti-D were present, hemolytic disease was more severe than when IgG1 alone was detected. The earliest onset of hydrops was at 20 weeks gestation in the IgG1 + IgG3 anti-Rh group, and at 27 weeks gestation in the IgG1 group.

摘要

在98例妊娠中，研究了抗Rh（D）IgG亚类对新生儿溶血病严重程度的影响。在仅检测到IgG1的32例病例中，19例病情严重；在同时检测到IgG1和IgG3的63例病例中，40例病情严重；而在仅检测到IgG3的3例病例中，无病情严重者。当同时存在IgG1和IgG3抗-D时，溶血病比仅检测到IgG1时更严重。IgG1 + IgG3抗Rh组最早出现水肿的孕周为妊娠20周，IgG1组为妊娠27周。