评估一种在美国多地点经期出血女性队列中用于出血性疾病的筛查工具。
Evaluation of a screening tool for bleeding disorders in a US multisite cohort of women with menorrhagia.
机构信息
Division of Hematology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA.
出版信息
Am J Obstet Gynecol. 2011 Mar;204(3):209.e1-7. doi: 10.1016/j.ajog.2010.10.897. Epub 2011 Jan 17.
Abstract
OBJECTIVE
The purpose of this study was to determine the usefulness of a simple screening tool for bleeding disorders in a multisite population of women with menorrhagia.
STUDY DESIGN
Women with menorrhagia between the ages of 18 and 50 years from 6 geographically diverse US centers underwent hemostatic testing for bleeding disorders, complete blood cell count, and ferritin. A questionnaire that contained all elements of the 8-question screening tool was administered. Sensitivity of the screening tool, a screening tool with a pictorial blood assessment chart (PBAC) score of >185, and a screening tool with serum ferritin were calculated for hemostatic disorders.
RESULTS
Two hundred and seventeen women who were identified with a PBAC score of ≥100 participated in the study. The sensitivity of the screening tool was 89% for hemostatic defects, and sensitivity increased to 93% and 95% with a serum ferritin level of ≤20 ng/mL and a PBAC score of >185, respectively.
CONCLUSION
This study confirms the usefulness of a short screening tool for the stratification of women with menorrhagia for hemostatic evaluation.
摘要
目的
本研究旨在确定一种简单的出血性疾病筛查工具在患有月经过多的多地点女性人群中的有用性。
研究设计
来自美国 6 个地理位置不同的中心的年龄在 18 至 50 岁之间的月经过多女性接受了止血性疾病检测、全血细胞计数和铁蛋白检查。还对包含 8 个问题筛查工具所有内容的问卷进行了管理。计算了筛查工具、具有>185 分的图片式血液评估图表（PBAC）评分的筛查工具和血清铁蛋白对止血障碍的敏感性。
结果
有 217 名 PBAC 评分≥100 的女性被确定参加了该研究。筛查工具对止血缺陷的敏感性为 89%，而当血清铁蛋白水平≤20ng/mL 和 PBAC 评分>185 时，敏感性分别增加至 93%和 95%。
结论
本研究证实了一种简短的筛查工具对于分层患有月经过多的女性进行止血评估的有用性。
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