Arnaoutoglou Eleni, Kouvelos George, Milionis Haralampos, Mavridis Anestis, Kolaitis Nikolaos, Papa Nektario, Papadopoulos George, Matsagkas Miltiadis
Department of Anesthesiology, School of Medicine, University of Ioannina, Ioannina, Greece.
Interact Cardiovasc Thorac Surg. 2011 Apr;12(4):609-14. doi: 10.1510/icvts.2010.256784. Epub 2011 Jan 19.
Endovascular aneurysm repair (EVAR), may elicit an unexpected systemic inflammatory response, which has been named post-implantation syndrome (PIS). The aim of this study was to prospectively evaluate the association of PIS with clinical and laboratory parameters in patients who underwent EVAR for abdominal aortic aneurysms (AAA).
Forty consecutive patients who underwent EVAR for AAA were studied. Complete blood count, fibrinogen, high sensitivity C-reactive protein (hs-CRP), interleukin (IL)-6, IL-1, tumor necrosis factor-alpha were determined before and after surgery. Several parameters regarding the operation, as well as the hospitalization days were recorded.
PIS was diagnosed in 35% of the patients. Patients with PIS showed significant greater changes of inflammation marker levels, including hs-CRP and IL-6, as compared with the non-PIS group. PIS was associated with longer hospitalization.
PIS is a relatively common complication of EVAR used to treat AAAs and it is associated with features of a systemic inflammatory response and prolongation of hospitalization. Further studies are necessary towards understanding the underlying pathophysiology and evaluating effective preventive strategies.
血管内动脉瘤修复术（EVAR）可能引发意想不到的全身炎症反应，这种反应被称为植入后综合征（PIS）。本研究的目的是前瞻性评估接受EVAR治疗腹主动脉瘤（AAA）患者的PIS与临床及实验室参数之间的关联。
对40例连续接受EVAR治疗AAA的患者进行研究。在手术前后测定全血细胞计数、纤维蛋白原、高敏C反应蛋白（hs-CRP）、白细胞介素（IL）-6、IL-1、肿瘤坏死因子-α。记录与手术相关的几个参数以及住院天数。
35%的患者被诊断为PIS。与非PIS组相比，PIS患者的炎症标志物水平，包括hs-CRP和IL-6，有显著更大的变化。PIS与住院时间延长有关。
PIS是用于治疗AAA的EVAR相对常见的并发症，它与全身炎症反应特征及住院时间延长有关。有必要进一步研究以了解潜在的病理生理学并评估有效的预防策略。
