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调控 DNA 超螺旋结构:精子指引方向。

Regulating DNA supercoiling: sperm points the way.

机构信息

Department of Anatomy, Biochemistry & Physiology, Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawaii at Manoa, 1960 East-West Road, Honolulu, HI 96822, USA.

出版信息

Biol Reprod. 2011 May;84(5):841-3. doi: 10.1095/biolreprod.111.090951. Epub 2011 Jan 19.

Abstract

In this issue, Meyer-Ficca et al. demonstrate that PARP1 and PARG regulate TOP2B mediated DNA double-strand breaks during spermiogenesis.

摘要

本期杂志中,Meyer-Ficca 等人研究表明,在精子发生过程中,PARP1 和 PARG 可调节 TOP2B 介导的 DNA 双链断裂。

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