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调控 DNA 超螺旋结构：精子指引方向。

Regulating DNA supercoiling: sperm points the way.

机构信息

Department of Anatomy, Biochemistry & Physiology, Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawaii at Manoa, 1960 East-West Road, Honolulu, HI 96822, USA.

出版信息

Biol Reprod. 2011 May;84(5):841-3. doi: 10.1095/biolreprod.111.090951. Epub 2011 Jan 19.

DOI:10.1095/biolreprod.111.090951
PMID:21248288
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3080416/
Abstract

In this issue, Meyer-Ficca et al. demonstrate that PARP1 and PARG regulate TOP2B mediated DNA double-strand breaks during spermiogenesis.

摘要

本期杂志中，Meyer-Ficca 等人研究表明，在精子发生过程中，PARP1 和 PARG 可调节 TOP2B 介导的 DNA 双链断裂。

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Regulating DNA supercoiling: sperm points the way.调控 DNA 超螺旋结构：精子指引方向。
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2
Poly(ADP-ribose) polymerases PARP1 and PARP2 modulate topoisomerase II beta (TOP2B) function during chromatin condensation in mouse spermiogenesis.多聚（ADP-核糖）聚合酶 PARP1 和 PARP2 在小鼠精子发生过程中的染色质浓缩过程中调节拓扑异构酶 IIβ（TOP2B）的功能。
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本文引用的文献

1
Poly(ADP-ribose) polymerases PARP1 and PARP2 modulate topoisomerase II beta (TOP2B) function during chromatin condensation in mouse spermiogenesis.多聚（ADP-核糖）聚合酶 PARP1 和 PARP2 在小鼠精子发生过程中的染色质浓缩过程中调节拓扑异构酶 IIβ（TOP2B）的功能。
Biol Reprod. 2011 May;84(5):900-9. doi: 10.1095/biolreprod.110.090035. Epub 2011 Jan 12.
2
The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets.核内的 PARP 侧：分子作用、生理结果和临床靶标。
Mol Cell. 2010 Jul 9;39(1):8-24. doi: 10.1016/j.molcel.2010.06.017.
3
Topoisomerase II-mediated breaks in spermatozoa cause the specific degradation of paternal DNA in fertilized oocytes.拓扑异构酶II介导的精子断裂导致受精卵中父本DNA的特异性降解。
Biol Reprod. 2007 Apr;76(4):666-72. doi: 10.1095/biolreprod.106.057067. Epub 2006 Dec 20.
4
Topoisomerase IIB and an extracellular nuclease interact to digest sperm DNA in an apoptotic-like manner.拓扑异构酶IIB与一种细胞外核酸酶相互作用，以凋亡样方式消化精子DNA。
Biol Reprod. 2006 Nov;75(5):741-8. doi: 10.1095/biolreprod.106.055178. Epub 2006 Aug 16.
5
Human topoisomerase IIalpha rapidly relaxes positively supercoiled DNA: implications for enzyme action ahead of replication forks.人类拓扑异构酶IIα能快速松弛正超螺旋DNA：对复制叉前酶作用的启示。
J Biol Chem. 2005 Nov 25;280(47):39337-45. doi: 10.1074/jbc.M503320200. Epub 2005 Sep 27.
6
On the nature and origin of DNA strand breaks in elongating spermatids.关于延长精子细胞中DNA链断裂的性质和起源
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