Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
NUPPA, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Int J Mol Sci. 2018 Sep 14;19(9):2765. doi: 10.3390/ijms19092765.
Type II DNA topoisomerases (EC 5.99.1.3) are enzymes that catalyse topological changes in DNA in an ATP dependent manner. Strand passage reactions involve passing one double stranded DNA duplex (transported helix) through a transient enzyme-bridged break in another (gated helix). This activity is required for a range of cellular processes including transcription. Vertebrates have two isoforms: topoisomerase IIα and β. Topoisomerase IIβ was first reported in 1987. Here we review the research on DNA topoisomerase IIβ over the 30 years since its discovery.
II 型 DNA 拓扑异构酶（EC5.99.1.3）是一类在 ATP 依赖的方式下催化 DNA 拓扑结构变化的酶。链穿越反应涉及将一条双链 DNA 双螺旋（转运螺旋）穿过另一条暂时的酶桥接断裂（门控螺旋）。这种活性是一系列细胞过程所必需的，包括转录。脊椎动物有两种同工酶：拓扑异构酶 IIα 和 β。拓扑异构酶 IIβ 于 1987 年首次报道。本文综述了自发现以来 30 年来 DNA 拓扑异构酶 IIβ 的研究进展。
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