School of Mathematics and Statistics, Newcastle University, Newcastle upon Tyne, UK.
J Hum Hypertens. 2011 Dec;25(12):719-24. doi: 10.1038/jhh.2010.122. Epub 2011 Jan 20.
The genotype at the C-11377G single-nucleotide polymorphism (SNP) (rs266729) in the adiponectin gene promoter has been shown to affect the prevalence of coronary atherosclerosis and incidence of vascular events in men, and to affect carotid intima media thickness. We have examined the relationship between this polymorphism and blood pressure in a cohort ascertained to express variability in blood pressure measurements. We studied a cohort of 255 families comprising 1425 individuals ascertained via a hypertensive proband. Blood pressure was measured by ambulatory monitoring. The C-11377G SNP was genotyped using a TaqMan assay. There was evidence of association between this SNP and log systolic blood pressure (SBP), having adjusted for significant covariates including gender, age and drug treatment; P=0.009, 0.014 and 0.022, respectively, for daytime, night-time and clinic measurements. Replacing C by G caused an increase of 1.63, 1.83 and 1.61%, respectively, per gene copy. There were smaller effects on diastolic blood pressure and waist-hip ratio, which were of borderline significance. Genotype at the C-11377G (rs266729) polymorphism has independent effects both on waist-hip ratio and SBP. This may help in understanding the complex role that the adiponectin gene has in atherosclerosis.
载脂蛋白基因启动子处 C-11377G 单核苷酸多态性 (SNP) (rs266729) 的基因型已被证明会影响男性冠状动脉粥样硬化的患病率和血管事件的发生率，并影响颈动脉内膜中层厚度。我们已经在一个血压测量值存在变异性的队列中检查了这种多态性与血压之间的关系。我们研究了一个由通过高血压先证者确定的 255 个家族组成的队列，共包含 1425 名个体。血压通过动态监测进行测量。使用 TaqMan 测定法对 C-11377G SNP 进行基因分型。该 SNP 与日志收缩压 (SBP) 之间存在关联的证据，调整了包括性别、年龄和药物治疗在内的显著协变量；白天、夜间和诊所测量时，P 值分别为 0.009、0.014 和 0.022。每个基因拷贝的 C 替换为 G 分别导致 SBP 增加 1.63%、1.83%和 1.61%。对舒张压和腰臀比的影响较小，具有边缘显著性。C-11377G(rs266729) 多态性的基因型对腰臀比和 SBP 均有独立影响。这可能有助于理解脂联素基因在动脉粥样硬化中的复杂作用。
