Patel Sheila, Flyvbjerg Allan, Kozàkovà Michaela, Frystyk Jan, Ibrahim Ibrahim M, Petrie John R, Avery Peter J, Ferrannini Ele, Walker Mark
Department of Medicine, University of Melbourne, Austin Health, Heidelberg Repatriation Hospital, Victoria, Australia.
Eur Heart J. 2008 Feb;29(3):386-93. doi: 10.1093/eurheartj/ehm526. Epub 2007 Dec 15.
The ADIPOQ gene encodes the protein adiponectin, and decreased circulating adiponectin levels have been observed in cardiovascular disease. We investigated the role of the ADIPOQ gene single-nucleotide polymorphisms (SNPs) A-11426G, G-11391A, C-11377G, and T45G with plasma adiponectin levels and common carotid artery intima media thickness (IMT) in a cohort of healthy subjects participating in the RISC (Relationship between Insulin Sensitivity and Cardiovascular disease) study.
Anthropometric and metabolic assessment and B-mode ultrasound of the carotid IMT were measured in 1306 subjects [589 men; 717 women, mean +/- SD age 43.8 +/- 8.3 years, BMI 25.5 +/- 4.0 kg/m(2)] recruited from 19 centres in 14 European countries. Carriers of the -11426G allele and homozygous carriers of the -11391G allele had significantly lower plasma adiponectin levels. These relationships remained significant after adjusting for age, sex, recruitment centre, and BMI. Carriers of SNP -11377G allele had significantly greater IMT values compared with C allele homozygotes [geometric mean (interquartile range) 601 (543-665) vs. 590 (537-647) mum, P = 0.021]. This relationship became stronger after correcting for key covariates, including plasma adiponectin levels (P = 0.011).
Variation within the ADIPOQ gene promoter is directly associated with carotid IMT in healthy subjects and is independent of circulating adiponectin levels.
ADIPOQ基因编码脂联素蛋白，在心血管疾病中已观察到循环脂联素水平降低。我们在参与RISC（胰岛素敏感性与心血管疾病关系）研究的一组健康受试者中，研究了ADIPOQ基因单核苷酸多态性（SNP）A-11426G、G-11391A、C-11377G和T45G与血浆脂联素水平及颈总动脉内膜中层厚度（IMT）的关系。
对来自14个欧洲国家19个中心招募的1306名受试者[589名男性；717名女性，平均±标准差年龄43.8±8.3岁，体重指数25.5±4.0kg/m²]进行人体测量和代谢评估，并对颈动脉IMT进行B型超声检查。-11426G等位基因携带者和-11391G等位基因纯合子携带者的血浆脂联素水平显著较低。在调整年龄、性别、招募中心和体重指数后，这些关系仍然显著。与C等位基因纯合子相比，SNP -11377G等位基因携带者的IMT值显著更高[几何平均数（四分位间距）601（543-665）对590（537-647）μm，P = 0.021]。在校正包括血浆脂联素水平在内的关键协变量后，这种关系变得更强（P = 0.011）。
ADIPOQ基因启动子内的变异与健康受试者的颈动脉IMT直接相关，且独立于循环脂联素水平。
