Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9148, USA.
Nature. 2011 Jan 20;469(7330):336-42. doi: 10.1038/nature09783.
First recognized as regulators of development in worms and fruitflies, microRNAs are emerging as pivotal modulators of mammalian cardiovascular development and disease. Individual microRNAs modulate the expression of collections of messenger RNA targets that often have related functions, thereby governing complex biological processes. The wideranging functions of microRNAs in the cardiovascular system have provided new perspectives on disease mechanisms and have revealed intriguing therapeutic targets, as well as diagnostics, for a variety of cardiovascular disorders.
最初在蠕虫和果蝇中被认为是发育的调控因子，microRNAs 正在成为哺乳动物心血管发育和疾病的关键调节因子。单个 microRNAs 调节信使 RNA 靶标的集合的表达，这些靶标通常具有相关的功能，从而控制复杂的生物学过程。microRNAs 在心血管系统中的广泛功能为疾病机制提供了新的视角，并揭示了各种心血管疾病的有趣治疗靶点以及诊断方法。
