Landin K, Lönnroth P, Krotkiewski M, Holm G, Smith U
Department of Medicine II, Sahlgrenska Hospital, University of Götteborg, Sweden.
Eur J Clin Invest. 1990 Oct;20(5):530-5. doi: 10.1111/j.1365-2362.1990.tb01897.x.
Increased lipolysis in abdominal adipocytes has been suggested to be of importance for the insulin resistance typical for abdominal obesity. In order to differentiate between fat distribution, measured as waist/hip ratio (WHR), and amount of body fat, glucose disposal during a euglycaemic clamp as well as lipolysis in isolated cells from abdominal and gluteo-femoral regions were studied in 20 obese and 20 lean postmenopausal women with a high (n = 10) and low (n = 10) WHR, respectively. The lipolytic response was increased in cells from obese women irrespective of region. Furthermore, lipolysis was enhanced in abdominal compared with the gluteo-femoral cells in obese women with a high WHR. Fasting blood glucose and insulin were increased in both groups of obese women while the degree of insulin resistance was most pronounced in the obese women with a high WHR. It is concluded that increased body fat is associated with both insulin resistance and increased lipolysis, and that this relationship is stronger in the presence of a high WHR. A high WHR may increase the expression of obesity as a risk for insulin resistance and this may be mediated through an increased lipolytic rate.
腹部脂肪细胞中脂肪分解增加被认为对于腹型肥胖典型的胰岛素抵抗具有重要意义。为了区分以腰臀比（WHR）衡量的脂肪分布和体脂量，对20名肥胖和20名消瘦的绝经后女性进行了研究，她们分别具有高（n = 10）和低（n = 10）WHR，研究内容包括正常血糖钳夹期间的葡萄糖处置以及腹部和臀股区域分离细胞中的脂肪分解。无论区域如何，肥胖女性细胞中的脂肪分解反应均增加。此外，在高WHR的肥胖女性中，与臀股细胞相比，腹部细胞的脂肪分解增强。两组肥胖女性的空腹血糖和胰岛素均升高，而胰岛素抵抗程度在高WHR的肥胖女性中最为明显。得出的结论是，体脂增加与胰岛素抵抗和脂肪分解增加均相关，并且在高WHR的情况下这种关系更强。高WHR可能会增加肥胖作为胰岛素抵抗风险的表现，这可能是通过增加脂肪分解速率来介导的。
