Hanssler L, Rosenthal E, Fitza B
Klinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum der Gesamthochschule Essen.
Klin Padiatr. 1990 Nov-Dec;202(6):379-82. doi: 10.1055/s-2007-1025549.
Listeriosis of the newborn is a relatively rare disease, presenting with clinical signs of septicemia. Early onset disease, resembling group B streptococcal septicemia, is already transmitted from the mother to the fetus and is associated with high morbidity and mortality. Late onset septicemia occurs as sporadic or as epidemic disease, usually beyond the fifth day of life. Epidemics can be caused by consumption of contaminated food or by nosocomial infections in neonatal units. Phage typing offers an opportunity to elucidate the route of transmission. During a 7 years period, 5 neonates ware diagnosed to have early onset, 1 newborn to have late onset Listeriosis. They all showed signs of bacterial septicemia with typical changes of white blood cell count, elevated CRP, hepatomegaly, and severe pneumonia. In all patients Listeria monocytogenes could be isolated from blood cultures. Serological tests were negative in all cases. 3 patients died. Nosocomial transmission of Listeria monocytogenes from one infant to another was proven by phage typing.
新生儿李斯特菌病是一种相对罕见的疾病，表现为败血症的临床症状。早发型疾病类似于B组链球菌败血症，已从母亲传播给胎儿，且发病率和死亡率很高。晚发型败血症呈散发性或流行性，通常在出生后第五天以后发病。疫情可能由食用受污染的食物或新生儿病房的医院感染引起。噬菌体分型为阐明传播途径提供了机会。在7年期间，5名新生儿被诊断为早发型，1名新生儿为晚发型李斯特菌病。他们均表现出细菌败血症的症状，伴有白细胞计数的典型变化、CRP升高、肝肿大和严重肺炎。所有患者的血培养均分离出单核细胞增生李斯特菌。所有病例的血清学检测均为阴性。3例患者死亡。通过噬菌体分型证实了单核细胞增生李斯特菌在医院内从一名婴儿传播给另一名婴儿。
