Le Monnier A, Leclercq A
Centre national de référence des Listeria et centre collaborateur de l'Organisation mondiale de la santé pour la listériose d'origine alimentaire, Institut Pasteur, 25, rue du Docteur-Roux, 75724 Paris cedex 15, France.
Pathol Biol (Paris). 2009 Feb;57(1):17-22. doi: 10.1016/j.patbio.2008.07.026. Epub 2008 Oct 1.
Listeria monocytogenes is a bacterium widely spread in the environment. Its persistence in industrial environment leads to food product contamination from the raw materials and constitutes a recurrent problem in food processing industry despite the use of cold chain procedures. L. monocytogenes is a foodborne pathogen causing severe and life-threatening infections that evolve mainly under sporadic mode, even if epidemics sometimes occur. Listeriosis causes mainly septicemia, central nervous system infections (meningitis and meningoencephalitis) and abortions. Listeriosis occurs primarily at risk groups of population like elderly people, pregnant women, neonates and patients with underlying diseases or impaired cellular immunity. In France, the epidemiological surveillance of listeriosis is based on two complementary approaches: the mandatory notification and the microbiological characterization by the National Reference Centre for Listeria of L. monocytogenes strains isolated from patients. The joined efforts of government and food producers have led to decrease significantly the incidence of listeriosis in France since 20 years and the number of epidemics. However, the recent observation of increasing number of listeriosis cases in most of the industrialised countries calls up to the attentiveness to reconsider the current rules and to reinforce the epidemiological surveillance of listeriosis in a context where susceptible people including the elderly are in increasing number.
单核细胞增生李斯特菌是一种广泛存在于环境中的细菌。它在工业环境中的持续存在会导致原材料污染食品,尽管采用了冷链程序,但这仍是食品加工业中反复出现的问题。单核细胞增生李斯特菌是一种食源性病原体,可引起严重的、危及生命的感染,主要以散发形式传播,不过有时也会发生疫情。李斯特菌病主要导致败血症、中枢神经系统感染(脑膜炎和脑膜脑炎)以及流产。李斯特菌病主要发生在老年人、孕妇、新生儿以及患有基础疾病或细胞免疫功能受损的人群等高危人群中。在法国,李斯特菌病的流行病学监测基于两种互补的方法:强制通报以及由国家李斯特菌参考中心对从患者中分离出的单核细胞增生李斯特菌菌株进行微生物特征分析。自20年前以来,政府和食品生产商的共同努力已使法国李斯特菌病的发病率和疫情数量大幅下降。然而,最近在大多数工业化国家观察到李斯特菌病病例数量不断增加,这提醒人们要保持警惕,重新审视现行规则,并在包括老年人在内的易感人群数量不断增加的背景下加强李斯特菌病的流行病学监测。