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干扰素抗性和敏感的L1210细胞中干扰素作用的比较。

Comparison of interferon action in interferon resistant and sensitive L1210 cells.

作者信息

Vandenbussche P, Content J, Lebleu B, Werenne J

出版信息

J Gen Virol. 1978 Oct;41(1):161-6. doi: 10.1099/0022-1317-41-1-161.

DOI:10.1099/0022-1317-41-1-161
PMID:212514
Abstract

Translation inhibition, leu-tRNA aminoacylation and double-stranded RNA and ATP dependent phosphorylation were examined in interferon-treated and control cell-free lysates of leukaemic mouse L 1210 R and L 1210 S cells. No differences were observed between the respective interferon-treated and control cell-free extracts, except for the presence of an enhanced 67K dalton phosphoprotein fraction in interferon-treated L 1210 S cell-free extracts. In non-responding cell-free lysates, the lack of stimulation of a 67K dalton phosphoprotein fraction cannot be explained by the presence of an increased level of some inhibitory activity, such as a phosphatase.

摘要

在经干扰素处理的和对照的白血病小鼠L 1210 R和L 1210 S细胞的无细胞裂解物中,检测了翻译抑制、亮氨酸-tRNA氨基酰化以及双链RNA和ATP依赖性磷酸化。除了在经干扰素处理的L 1210 S细胞无细胞提取物中存在增强的67K道尔顿磷蛋白组分外,在各自经干扰素处理的和对照的无细胞提取物之间未观察到差异。在无反应的无细胞裂解物中,67K道尔顿磷蛋白组分缺乏刺激不能用某些抑制活性(如磷酸酶)水平升高来解释。

相似文献

1
Comparison of interferon action in interferon resistant and sensitive L1210 cells.干扰素抗性和敏感的L1210细胞中干扰素作用的比较。
J Gen Virol. 1978 Oct;41(1):161-6. doi: 10.1099/0022-1317-41-1-161.
2
Effects of interferon on vesicular stomatitis virus transcription and translation.干扰素对水疱性口炎病毒转录和翻译的影响。
J Gen Virol. 1977 May;35(2):325-34. doi: 10.1099/0022-1317-35-2-325.
3
Specific protein phosphorylation in interferon-treated uninfected and virus-infected mouse L929 cells: enhancement by double-stranded RNA.干扰素处理的未感染及病毒感染的小鼠L929细胞中的特异性蛋白质磷酸化:双链RNA的增强作用
J Virol. 1979 Jan;29(1):301-11. doi: 10.1128/JVI.29.1.301-311.1979.
4
Effects of interferon on sensitive and resistant L1210 cell lines.干扰素对敏感和耐药L1210细胞系的作用。
J Interferon Res. 1981 Feb;1(2):287-95. doi: 10.1089/jir.1981.1.287.
5
Rapid increase in guanosine 3',5'-cyclic-monophosphate interferon treated mouse leukemia L1210 cells: relationship to the development of the antiviral state and inhibition of cell multiplication.
Virology. 1981 Dec;115(2):272-81. doi: 10.1016/0042-6822(81)90110-0.
6
Messenger RNA methylation, translation and degradation in extracts of interferon-treated cells.干扰素处理细胞提取物中的信使核糖核酸甲基化、翻译及降解
Tex Rep Biol Med. 1977;35:221-9.
7
Effect of interferon on transcription and translation of vesicular stomatitis virus in human and simian cell cultures.干扰素对人及猴细胞培养中水泡性口炎病毒转录和翻译的影响。
J Gen Virol. 1978 Nov;41(2):421-6. doi: 10.1099/0022-1317-41-2-421.
8
Interferon-induced inhibition of protein synthesis in L-cell extracts: an ATP-dependent step in the activation of an inhibitor by double-stranded RNA.干扰素诱导的L细胞提取物中蛋白质合成的抑制:双链RNA激活抑制剂过程中依赖ATP的步骤。
Proc Natl Acad Sci U S A. 1976 Sep;73(9):3136-40. doi: 10.1073/pnas.73.9.3136.
9
Molecular mechanisms of interferon action: interferon-mediated phosphorylation of ribosome-associated protein P1 and protein synthesis initiation factor eIF-2.干扰素作用的分子机制:干扰素介导的核糖体相关蛋白P1和蛋白质合成起始因子eIF-2的磷酸化
Tex Rep Biol Med. 1981;41:463-70.
10
Inhibition of RNA and protein synthesis in interferon-treated HeLa cells infected with vesicular stomatitis virus.在感染水疱性口炎病毒的经干扰素处理的HeLa细胞中RNA和蛋白质合成的抑制作用
J Gen Virol. 1980 Apr;47(2):373-84. doi: 10.1099/0022-1317-47-2-373.

引用本文的文献

1
5'-O-Monophosphoryladenylyl(2' goes to 5')adenylyl(2' goes to 5')adenosine is an antagonist of the action of 5'-O-triphosphoryladenylyl-(2' goes to 5')adenylyl(2' goes to 5')adenosine and double-stranded RNA.5'-O-单磷酸腺苷(2'至5')腺苷(2'至5')腺苷是5'-O-三磷酸腺苷(2'至5')腺苷(2'至5')腺苷和双链RNA作用的拮抗剂。
Proc Natl Acad Sci U S A. 1981 Oct;78(10):5993-7. doi: 10.1073/pnas.78.10.5993.
2
Interferon-specific effects on protein synthesis in P3HR-1 cells.干扰素对P3HR - 1细胞蛋白质合成的特异性作用。
EMBO J. 1982;1(12):1505-11. doi: 10.1002/j.1460-2075.1982.tb01347.x.
3
Biochemical analysis of mutants of a macrophage cell line resistant to the growth-inhibitory activity of interferon.
对一种对干扰素生长抑制活性具有抗性的巨噬细胞系突变体的生化分析。
J Cell Biol. 1984 Apr;98(4):1342-7. doi: 10.1083/jcb.98.4.1342.
4
Abnormal behavior of interferon-induced enzymatic activities in an interferon-resistant cell line.干扰素抗性细胞系中干扰素诱导酶活性的异常行为。
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4479-83. doi: 10.1073/pnas.77.8.4479.