Dallal A, Fontaine R, Ontiveros A, Elie R
Department of Psychiatry, Jewish General Hospital, Montreal, Quebec.
Can J Psychiatry. 1990 Oct;35(7):608-11. doi: 10.1177/070674379003500709.
An open clinical study with 20 consecutive outpatients suffering from major depression with melancholia (DSM-III) was carried out. All patients were resistant to desipramine after at least six weeks of treatment. A significant improvement was found in 13 of the 20 patients when lithium carbonate was added. Among the responder patients, five improved in the first week of lithium augmentation, while eight others improved after one week of lithium. The mechanism of action of the lithium augmentation effect in tricyclic-resistant depressed patients is discussed in view of our findings. We suggest that the unified 5-HT/NE hypothesis used in affective disorder could be applied in drug refractory depression.
对20例连续性门诊重性抑郁伴 melancholia（DSM-III）患者进行了一项开放性临床研究。所有患者在至少六周的治疗后对去甲丙咪嗪耐药。当添加碳酸锂后，20例患者中有13例有显著改善。在有反应的患者中，5例在加用锂盐的第一周病情改善，另外8例在加用锂盐一周后改善。根据我们的研究结果，讨论了锂盐增效作用在三环类耐药抑郁患者中的作用机制。我们建议，情感障碍中使用的统一5-羟色胺/去甲肾上腺素假说可应用于药物难治性抑郁症。
