Price L H, Delgado P L, Charney D S, Heninger G R
Department of Psychiatry, Yale University School of Medicine, New Haven, CT.
J Clin Psychiatry. 1988 Apr;49(4):161-2.
A 25-year-old man was hospitalized twice for melancholia. During the first hospitalization he had no response to a trial of desipramine but improved after the addition of lithium; during the second hospitalization he had no response to lithium but improved after the addition of desipramine. Concurrent administration of lithium and a tricyclic may be effective in some patients who respond to neither drug alone, but the sequence of drug administration may not be a critical factor.
一名25岁男性因忧郁症住院两次。在第一次住院期间，他对去甲丙咪嗪试验无反应，但加用锂盐后病情改善；在第二次住院期间，他对锂盐无反应，但加用去甲丙咪嗪后病情改善。对于单独使用两种药物均无反应的一些患者，锂盐和三环类药物联合使用可能有效，但给药顺序可能不是关键因素。
