Department of Neurology, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Japan.
Dement Geriatr Cogn Disord. 2010;30(6):479-85. doi: 10.1159/000322057. Epub 2011 Jan 20.
BACKGROUND/AIMS: The aim of this study is to examine whether metabolic syndrome is directly associated with cognitive impairment independent of subclinical ischemic brain lesions.
We examined 1,543 neurologically normal subjects (44-86 years of age). Metabolic syndrome, brain MRI, and cognitive functions including general cognition and executive function were assessed.
After adjusting for silent brain lesions and demographic risk factors, metabolic syndrome was an independent risk factor for impairment of executive function (OR = 1.41, 95% CI = 1.17-1.25 for Kohs' Test; OR = 2.25, 95% CI = 1.64-3.07 for Frontal Assessment Battery). Among the components of metabolic syndrome, elevated fasting glucose was the only independent risk factor for impairment of executive function.
Metabolic syndrome is associated with impairment of executive function independent of silent brain lesions in the Japanese population.
背景/目的：本研究旨在探讨代谢综合征是否与认知障碍有关，而不受亚临床缺血性脑损伤的影响。
我们检查了 1543 名神经正常的受试者（44-86 岁）。评估了代谢综合征、脑 MRI 和认知功能，包括一般认知和执行功能。
在调整了沉默性脑损伤和人口统计学风险因素后，代谢综合征是执行功能障碍的独立危险因素（Kohs 测试的比值比为 1.41，95%可信区间为 1.17-1.25；额叶评估电池的比值比为 2.25，95%可信区间为 1.64-3.07）。在代谢综合征的各个组成部分中，空腹血糖升高是唯一与执行功能障碍有关的独立危险因素。
在日本人群中，代谢综合征与执行功能障碍有关，而与沉默性脑损伤无关。
