Department of Biochemistry, Assiut University, Assiut, Egypt. ragaa_2002 @ yahoo.com
Med Princ Pract. 2011;20(2):124-8. doi: 10.1159/000321212. Epub 2011 Jan 20.
To investigate the role of biochemical changes in the umbilical cord and placenta in developing preeclampsia (PE).
Thirty women with PE and 15 healthy pregnant women as controls were enrolled in this study. Vascular endothelial growth factor (VEGF), soluble vascular endothelial growth factor receptor 1 (sVEGFR-1), platelet-derived endothelial cell growth factor (PD-ECGF), neutrophil elastase and nitric oxide (NO) were measured.
Both serum (maternal and fetal) and tissue (placenta and umbilical cord) levels of VEGF, sVEGFR-1, PD-ECGF and neutrophil elastase were significantly increased, whereas NO was significantly decreased (except placental tissue showed no changes) in preeclamptic patients. The cord serum level of PD-ECGF was significantly higher in severe PE compared to mild PE and normal pregnant women. The placental and cord tissue levels of PD-ECGF and neutrophil elastase were significantly higher in severe PE, while the cord tissue level of NO was significantly lower in severe PE.
Our data showed that umbilical cord vessels and stroma can serve as an additional source of vasoactive and angiogenic substances that contribute to the biochemical changes occurring in PE.
探讨脐带和胎盘组织中生化改变在子痫前期（PE）发病中的作用。
本研究纳入了 30 例 PE 患者和 15 例健康孕妇作为对照。测定血管内皮生长因子（VEGF）、可溶性血管内皮生长因子受体 1（sVEGFR-1）、血小板衍生内皮细胞生长因子（PD-ECGF）、中性粒细胞弹性蛋白酶和一氧化氮（NO）。
PE 患者血清（母体和胎儿）和组织（胎盘和脐带）中的 VEGF、sVEGFR-1、PD-ECGF 和中性粒细胞弹性蛋白酶水平显著升高，而 NO 水平显著降低（胎盘组织除外）。重度 PE 患者脐带血清 PD-ECGF 水平明显高于轻度 PE 和正常孕妇。重度 PE 患者胎盘和脐带组织中的 PD-ECGF 和中性粒细胞弹性蛋白酶水平显著升高，而重度 PE 患者脐带组织中的 NO 水平显著降低。
我们的数据表明，脐带血管和基质可以作为血管活性和血管生成物质的额外来源，这些物质有助于 PE 中发生的生化改变。
