自噬作用清除线粒体。
Mitochondria removal by autophagy.
机构信息
Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
出版信息
Autophagy. 2011 Mar;7(3):297-300. doi: 10.4161/auto.7.3.14502.
Abstract
Mitochondrial dysfunction has severe cellular consequences and is linked with neurodegenerative diseases and aging. Maintaining a healthy population of mitochondria is thus essential for proper cellular homeostasis. Several strategies have evolved to prevent and limit mitochondria damage, and macroautophagy plays a role in degrading superfluous or severely damaged mitochondria. Selective removal of mitochondria by autophagy (termed mitophagy) has been extensively studied recently in both yeast and mammalian cells. In this review, we summarize our current knowledge of mitophagy. We also compare the molecular process of mitophagy with other types of specific autophagic pathways and discuss its biological importance.
摘要
线粒体功能障碍会对细胞产生严重影响，并与神经退行性疾病和衰老有关。因此，维持健康的线粒体群体对于细胞内环境的稳定至关重要。已经进化出几种策略来预防和限制线粒体损伤，而巨自噬在降解多余或严重受损的线粒体方面发挥作用。自噬（称为线粒体自噬）选择性地去除线粒体，最近在酵母和哺乳动物细胞中都得到了广泛研究。在这篇综述中，我们总结了目前对线粒体自噬的认识。我们还将线粒体自噬的分子过程与其他类型的特异性自噬途径进行了比较，并讨论了其生物学重要性。
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