From the University of Texas Southwestern Medical Center, Dallas, Texas; and the Department of Obstetrics and Gynecology, Parkland Health and Hospital System, Dallas, Texas.
Obstet Gynecol. 2011 Feb;117(2 Pt 2):501-503. doi: 10.1097/AOG.0b013e318206bde4.
Sticky platelet syndrome is an autosomal-dominant thrombophilia characterized by platelet hyperaggregability in the presence of adenosine diphosphate or epinephrine. The result clinically can be widespread thromboses, often arterial, in patients without apparent risk factors for thrombotic disease. Limited data exist regarding its role in adverse pregnancy outcomes.
A gravid woman with two previous first-trimester miscarriages presented at 11 weeks of gestation with a deep venous thrombosis. Despite anticoagulation, she developed extensive and progressive arterial and venous thromboses and suffered a fetal demise. A thrombophilia panel was unremarkable, but platelet aggregometry demonstrated hyperactive platelets in the presence of adenosine diphosphate and epinephrine consistent with sticky platelet syndrome.
Sticky platelet syndrome causes arterial thromboses and may be an underappreciated etiology for adverse pregnancy outcomes.
黏附血小板综合征是一种常染色体显性遗传性血栓形成倾向，其特征是在存在二磷酸腺苷或肾上腺素的情况下血小板高聚集性。临床上可表现为广泛血栓形成，常为动脉血栓形成，患者无明显血栓形成疾病的危险因素。关于其在不良妊娠结局中的作用的相关数据有限。
一名孕妇，曾两次在妊娠早期流产，在妊娠 11 周时因深静脉血栓形成就诊。尽管进行了抗凝治疗，但她仍出现广泛进行性动脉和静脉血栓形成，并导致胎儿死亡。血栓形成倾向检查无明显异常，但血小板聚集试验显示，在存在二磷酸腺苷和肾上腺素的情况下血小板高反应性，符合黏附血小板综合征的特征。
黏附血小板综合征可导致动脉血栓形成，可能是不良妊娠结局被低估的病因之一。
