1 Universidad Popular Autónoma del Estado de Puebla, Puebla, Mexico.
2 Laboratorios Clínicos de Puebla, Puebla, Mexico.
Clin Appl Thromb Hemost. 2019 Jan-Dec;25:1076029619841700. doi: 10.1177/1076029619841700.
The sticky platelet syndrome (SPS) is a common cause of both arterial and venous thrombosis, being a dominant autosomal disease with qualitative platelet alterations and familial occurrence. It is characterized by platelet hyperreactivity with increased platelet aggregability in response to low concentrations of platelet agonists: epinephrine, adenosine diphosphate, or both. The clinical manifestations involve venous or arterial thrombosis, recurrent pregnancy loss, and fetal growth retardation. To analyze the localization of the thrombotic episodes in a cohort of Mexican mestizo patients with SPS. Between 1992 and 2016, 86 Mexican mestizo patients with SPS as the single thrombophilic condition were prospectively identified; all of them had a history of thrombosis. There were 15 males and 71 females. The thrombotic episodes were arterial in 26 cases and venous in 60 (70%). Arterial thrombosis was mainly pulmonary thromboembolism, whereas venous thromboses were identified most frequently in the lower limbs. Mexican mestizo population with SPS is mainly female; the type I of the condition is the most frequent; both arterial and venous thrombosis can occur, and they are mainly pulmonary embolism and lower limbs venous thrombosis, respectively.
黏附小板综合征（SPS）是动脉和静脉血栓形成的常见原因，是一种常染色体显性疾病，伴有血小板质量改变和家族性发生。其特征为血小板反应性增高，对低浓度血小板激动剂（肾上腺素、二磷酸腺苷或两者）的血小板聚集性增强。临床表现包括静脉或动脉血栓形成、复发性妊娠丢失和胎儿生长迟缓。为了分析黏附小板综合征墨西哥混血患者队列中血栓形成的定位。1992 年至 2016 年间，前瞻性确定了 86 例作为单一血栓形成倾向的黏附小板综合征墨西哥混血患者；所有患者均有血栓形成史。其中男性 15 例，女性 71 例。26 例为动脉血栓形成，60 例（70%）为静脉血栓形成。动脉血栓形成主要为肺血栓栓塞症，而静脉血栓形成最常见于下肢。黏附小板综合征的墨西哥混血人群主要为女性；I 型最常见；可发生动脉和静脉血栓形成，分别主要为肺栓塞和下肢静脉血栓形成。
