Department of Pediatrics, Section of Pediatric Infectious Diseases, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
J Perinatol. 2011 Jul;31(7):500-3. doi: 10.1038/jp.2010.197. Epub 2011 Jan 20.
To measure systemic haptoglobin (HPT) concentrations from birth in preterm (PT) and T newborns. To compare HPT in newborns without hemolysis or infection with values in bacteremic newborns.
HPT was measured using enzyme-linked immunosorbent assay in 30 PT and 28 T newborns without hemolysis or infection at birth (cord blood), on days of life 2 to 4, and at 1 to 2 weeks of life. Concentrations were measured in eight additional newborns with bacteremia. Wilcoxon-Mann-Whitney test was used for comparisons.
HPT concentrations were consistently measurable from birth in PT and T neonates. Values were significantly greater in 2- to 4-day-old PT and T newborns than in newborns at birth (P<0.01). Bacteremic newborns had higher HPT concentrations than newborns without infection (P=0.033).
HPT is detectable from birth in PT and T newborns. HPT concentrations increase in bacteremic newborns. HPT levels may have clinical utility in the evaluation of neonatal sepsis.
测量早产儿（PT）和足月产（T）新生儿从出生起的系统性结合珠蛋白（HPT）浓度。比较无溶血或感染的新生儿与菌血症新生儿的 HPT 值。
采用酶联免疫吸附试验（ELISA）在 30 例无溶血或感染的 PT 和 28 例 T 新生儿出生时（脐血）、生后 2-4 天以及生后 1-2 周测量 HPT。在另外 8 例菌血症新生儿中测量浓度。采用 Wilcoxon-Mann-Whitney 检验进行比较。
PT 和 T 新生儿从出生起即可持续测量 HPT 浓度。与出生时相比，2-4 日龄的 PT 和 T 新生儿的 HPT 值显著升高（P<0.01）。菌血症新生儿的 HPT 浓度高于无感染新生儿（P=0.033）。
PT 和 T 新生儿从出生起即可检测到 HPT。菌血症新生儿的 HPT 浓度增加。HPT 水平在评估新生儿败血症方面可能具有临床应用价值。
