Department of Urology, Pusan Paik Hospital, Inje University College of Medicine, Busan, Korea.
Int Neurourol J. 2010 Dec;14(4):227-31. doi: 10.5213/inj.2010.14.4.227. Epub 2010 Dec 31.
To investigate the short-term safety of antidiuretic hormone in elderly patients with nocturnal polyuria, focus on hyponatremia and others electrolytes disturbances and to assess short-term effects on nocturnal urine output and number of nocturnal voids.
Between June 2005 and August 2006, a total of 34 patients with nocturnal polyuria were orally administered 0.2 mg desmopressin tablet at bedtime for two weeks. Serum sodium, others electrolytes, urine sodium and urine osmolarity were assessed in the third days, one week and two weeks after treatment with desmopressin and compared adult group (<65 years of age) with elderly group (≥65 years of age). We assessed the effect of desmopressin using a frequency-volume charts and analysed.
In total 34 patients (20 adult, 14 elderly) were analyzed. Desmopressin treatment did not significantly change serum and urine electrolytes include soduim concentration in elderly patients comparied with adult patients. Serum sodium concentration below normal range was recorded in 2 patients in elderly group, but no serious adverse events occurred and recovered without sequelae. The mean number of nocturnal voids decresed (54% reduction) and nocturnal urine output decreased (57% reduction) after using desmopressin.
Desmopressin was well tolerated and effective in elderly patients with nocturnal polyuria without clinically significant hyponatremia.
研究抗利尿激素治疗老年夜间多尿症患者的短期安全性，重点关注低钠血症和其他电解质紊乱，并评估其对夜间尿量和夜间排尿次数的短期影响。
2005 年 6 月至 2006 年 8 月，共 34 例夜间多尿症患者在睡前口服 0.2mg 去氨加压素片，治疗两周。在治疗去氨加压素后第 3 天、第 1 周和第 2 周评估血清钠、其他电解质、尿钠和尿渗透压，并将成年组（<65 岁）与老年组（≥65 岁）进行比较。我们使用频率-体积图表评估去氨加压素的效果，并进行分析。
共分析了 34 例患者（20 例成年，14 例老年）。与成年患者相比，去氨加压素治疗并未显著改变老年患者的血清和尿液电解质，包括钠浓度。老年组有 2 例患者的血清钠浓度低于正常范围，但未发生严重不良事件，且无后遗症。使用去氨加压素后，夜间排尿次数减少（减少 54%），夜间尿量减少（减少 57%）。
去氨加压素在老年夜间多尿症患者中耐受良好且有效，无临床显著的低钠血症。
