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Small interfering RNA (siRNA): a hope for the loss-of-function studies in anesthesiology?

作者信息

Kim Yun Hong

机构信息

Department of Anesthesiology and Pain Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

出版信息

Korean J Anesthesiol. 2010 Dec;59(6):369-70. doi: 10.4097/kjae.2010.59.6.369. Epub 2010 Dec 31.

DOI:10.4097/kjae.2010.59.6.369
PMID:21253371
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3022127/
Abstract
摘要

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本文引用的文献

1
The optimal concentration of siRNA for gene silencing in primary cultured astrocytes and microglial cells of rats.用于基因沉默的大鼠原代培养星形胶质细胞和小胶质细胞中 siRNA 的最佳浓度。
Korean J Anesthesiol. 2010 Dec;59(6):403-10. doi: 10.4097/kjae.2010.59.6.403. Epub 2010 Dec 31.
2
Suppression of heart NF-κB p65 expression by jugular vein injection of RNAi in mice.通过向小鼠颈静脉注射RNAi抑制心脏NF-κB p65表达。
Methods Find Exp Clin Pharmacol. 2010 Jul-Aug;32(6):391-400. doi: 10.1358/mf.2010.32.6.1472186.
3
Pulmonary-derived phosphoinositide 3-kinase gamma (PI3Kγ) contributes to ventilator-induced lung injury and edema.肺源性磷酸肌醇 3-激酶γ(PI3Kγ)有助于呼吸机相关性肺损伤和水肿。
Intensive Care Med. 2010 Nov;36(11):1935-45. doi: 10.1007/s00134-010-2018-y. Epub 2010 Aug 19.
4
Advances in synthetic siRNA delivery.合成小干扰RNA递送技术的进展。
Discov Med. 2010 May;9(48):418-30.
5
Translocation of protein kinase C isoforms is involved in propofol-induced endothelial nitric oxide synthase activation.蛋白激酶 C 同工型的易位参与了异丙酚诱导的内皮型一氧化氮合酶激活。
Br J Anaesth. 2010 May;104(5):606-12. doi: 10.1093/bja/aeq064. Epub 2010 Mar 26.
6
Sevoflurane preconditioning induces rapid ischemic tolerance against spinal cord ischemia/reperfusion through activation of extracellular signal-regulated kinase in rabbits.七氟烷预处理通过激活细胞外信号调节激酶诱导兔脊髓缺血/再灌注快速缺血耐受。
Anesth Analg. 2009 Oct;109(4):1263-72. doi: 10.1213/ane.0b013e3181b2214c.
7
In vivo target validation using gene invalidation, RNA interference and protein functional knockout models: it is the time to combine.使用基因敲除、RNA干扰和蛋白质功能敲除模型进行体内靶点验证:是时候进行整合了。
Curr Opin Pharmacol. 2009 Oct;9(5):669-76. doi: 10.1016/j.coph.2009.06.017. Epub 2009 Jul 29.
8
Knocking down barriers: advances in siRNA delivery.消除障碍:小干扰RNA递送技术的进展
Nat Rev Drug Discov. 2009 Feb;8(2):129-38. doi: 10.1038/nrd2742.
9
Differential effects of alpha 2-adrenoceptors in the modulation of the thermoregulatory response in mice induced by meperidine.α2肾上腺素能受体在哌替啶诱导的小鼠体温调节反应调节中的差异作用。
Anesthesiology. 2008 Jul;109(1):95-100. doi: 10.1097/ALN.0b013e31817c02fc.
10
Off-target effects of siRNA specific for GFP.针对绿色荧光蛋白(GFP)的小干扰RNA(siRNA)的脱靶效应。
BMC Mol Biol. 2008 Jun 24;9:60. doi: 10.1186/1471-2199-9-60.