[生物制剂。神奇子弹——神奇效果——神奇成本？新型疗法及其影响]

[Biologics. Magic bullets - magic effects - magic costs? New therapeutics and their effects].

作者信息

Frey O, Kamradt T

机构信息

Institut für Immunologie, Universitätsklinikum Jena, Leutragraben 3, 07743 Jena.

出版信息

Ophthalmologe. 2011 Jan;108(1):7-12. doi: 10.1007/s00347-010-2255-z.

DOI:10.1007/s00347-010-2255-z

PMID:21253742

Abstract

Biologics and especially therapeutic monoclonal antibodies have an ever increasing impact in the therapy of inflammatory and malignant diseases. They allow a selective blockade of cytokines, receptors and other molecules. This review summarizes the immunological background, the current state and future trends in the development of these therapeutic agents.

摘要

生物制剂，尤其是治疗性单克隆抗体，在炎症性疾病和恶性疾病的治疗中发挥着越来越大的作用。它们能够选择性地阻断细胞因子、受体和其他分子。本综述总结了这些治疗药物的免疫学背景、当前状况及未来发展趋势。