Succaria Farah, Bhawan Jag
Section of Dermatopathology, Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts, USA.
J Dermatol. 2017 Mar;44(3):243-250. doi: 10.1111/1346-8138.13762.
Advances in understanding molecular mechanisms and targets in immune regulation have led to the widespread use of biologic targeted therapies, and, as such, reformed the course of many disabling diseases. However, with their expanded use, various side-effects, including cutaneous, have emerged. Many times a clear-cut relationship exists between the drug and the clinical manifestations; however, when a biopsy is warranted, various histopathological patterns may be observed and may cause confusion to the dermatopathologist. The aim of this review is to shed light on the different histopathological patterns observed as a manifestation secondary to biologics.
在免疫调节分子机制和靶点认识方面的进展导致了生物靶向治疗的广泛应用，因此改变了许多致残性疾病的病程。然而，随着其使用范围的扩大，包括皮肤方面在内的各种副作用也出现了。很多时候，药物与临床表现之间存在明确的关联；然而，当需要进行活检时，可能会观察到各种组织病理学模式，这可能会给皮肤病理学家带来困惑。本综述的目的是阐明作为生物制剂继发表现所观察到的不同组织病理学模式。
