Donbrow M, Touitou E
J Pharm Pharmacol. 1977 Sep;29(9):524-8. doi: 10.1111/j.2042-7158.1977.tb11388.x.
The dissolution rate of compressed salicylamide discs has been measured in water and in caffeine solutions of increasing concentration at 15, 25, 37 and 45 degrees in an apparatus rotating at 48 rev min-1 or more. Dissolution rate profiles showed breaks indicative of a shift in the mechanism of dissolution from interfacial towards transport control. The shifts occurred at higher caffeine concentrations on increasing the agitation rate or temperature. The dependencies of dissolution rates on agitation rates typified the intermediate type of dissolution and Arrhenius plots indicated that interfacial and transport processes participated in salicylamide dissolution.
在转速为48转/分钟或更高的装置中，于15、25、37和45摄氏度下，测定了压制的水杨酰胺片在水以及浓度不断增加的咖啡因溶液中的溶解速率。溶解速率曲线出现了断点，表明溶解机制从界面控制向扩散控制发生了转变。随着搅拌速率或温度的升高，在咖啡因浓度较高时发生了这种转变。溶解速率对搅拌速率的依赖性体现了中间类型的溶解，阿累尼乌斯曲线表明界面过程和扩散过程都参与了水杨酰胺的溶解。
