Donbrow M, Touitou E, Shalom H B
J Pharm Pharmacol. 1976 Oct;28(10):766-9. doi: 10.1111/j.2042-7158.1976.tb04044.x.
The stability constants for formation of complexes of salicylamide with caffeine have been measured between 15 and 45degrees, by means of the solubility method. There was a linear solubility increase at all temperatures but phase diagrams indicated that at 15 and 25degrees an additional phase was formed which was found to be an insoluble 1 : 1 complex. The enthalpies and entropies of interactions were evaluated. They indicate that the interaction is exothermic and enthalpy controlled.
通过溶解度法测定了水杨酰胺与咖啡因形成配合物的稳定常数，测定温度范围为15至45摄氏度。在所有温度下溶解度均呈线性增加，但相图表明，在15和25摄氏度时会形成一个额外的相，该相为不溶性1:1配合物。对相互作用的焓和熵进行了评估。结果表明，这种相互作用是放热的且受焓控制。
