Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York 11794-3400, USA.
Chem Asian J. 2011 Feb 1;6(2):674-80. doi: 10.1002/asia.201000697. Epub 2010 Dec 22.
A library of new 2,2'-bis(diphenylphosphinoyloxy)-1,1'-binaphthyl (binapo)-type chiral diphosphonite ligands was designed and synthesized based on chiral 3,3',5,5',6,6'-hexasubstituted biphenols. These bop ligands have exhibited excellent efficiency in a palladium-catalyzed intermolecular allylic amination reaction, which provides a key intermediate for the total synthesis of Strychnos indole alkaloids with enantiopurities of up to 96% ee.
基于手性 3,3',5,5',6,6'-六取代联苯酚，设计并合成了一种新的 2,2'-双（二苯膦酰氧基）-1,1'-联萘（binapo）型手性双膦氧配体库。这些 bop 配体在钯催化的分子间烯丙基氨化反应中表现出了优异的效率，为士的宁吲哚生物碱的全合成提供了关键的中间体，对映体过量值高达 96%ee。
