Xu Hui-Qing, Xing Jian-Min, Jia Ruo
Department of Anesthesiology, Wang Jing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China.
Zhongguo Gu Shang. 2010 Nov;23(11):838-40.
To observe the effects and side effects of Pentazocine for postoperative intravenous analgesia in patients with lumbar herniation, and to investigate the difference of Pentazocine with different doses.
From January 2009 to December 2009, sixty patients undergone laminectomy and pedicle internal fixation, who using equal analgesic dosage of Pentazocine and Sulfentanil, were retrospectively analysed. The patients including 34 males and 26 females, aged 40 to 65 (average 59), weighted 60 to 80 kg (average 71 kg), ASA I-II, were divided into Sufentanil group and Pentazocine group I and Pentazocine group II, with 20 cases each. The regimens of the three groups included: Sufentanil of 2 g/kg; Pentazocine group I of 3 mg/kg; Pentazocine group II of 5 mg/kg. All were diluted with saline into 100 ml and were continuously infused at the rate of 2 ml/h. Visual analogue scale (VAS), Ramsay sedation scale and side effects were recorded at 4, 8, 12, 24, 36, and 48 h postoperatively.
The three groups had no significant difference in analgesic effects, VAS of all groups were below 3. The sedation scale of Pentazocine group II at 4, 8, 12 h was higher than that at 4 h, significantly different than the other two groups. The incidence of nausea, vomiting and pruritus in Sufentanil group were higher than that in the other two groups. The incidence of respiratory depression in Sufentanil group and Pentazocine group II were higher than that in Pentazocine group II. The incidence of dizziness in Pentazocine group II were higher than that in the other two groups.
Pentazocine can produce reliable postoperative analgesia for patients with lumbar herniation, as same as the effect of sulfentanil in equal dose. And Pentazocine has fewer adverse effects compared with sufentanil. 3 mg/kg of Pentazocine is an optimal dose for postoperative intravenous patient-control analgesia.
观察喷他佐辛用于腰椎间盘突出症患者术后静脉镇痛的效果及不良反应，并探讨不同剂量喷他佐辛的差异。
回顾性分析2009年1月至2009年12月行椎板切除及椎弓根内固定术、使用等量镇痛剂量喷他佐辛和舒芬太尼的60例患者。患者包括34例男性和26例女性，年龄40至65岁（平均59岁），体重60至80 kg（平均71 kg），ASA I-II级，分为舒芬太尼组、喷他佐辛I组和喷他佐辛II组，每组20例。三组的方案包括：舒芬太尼2μg/kg；喷他佐辛I组3mg/kg；喷他佐辛II组5mg/kg。均用生理盐水稀释至100ml，以2ml/h的速度持续输注。术后4、8、12、24、36和48小时记录视觉模拟评分（VAS）、Ramsay镇静评分及不良反应。
三组镇痛效果无显著差异，各组VAS均低于3。喷他佐辛II组4、8、12小时的镇静评分高于4小时，与其他两组有显著差异。舒芬太尼组恶心、呕吐和瘙痒的发生率高于其他两组。舒芬太尼组和喷他佐辛II组呼吸抑制的发生率高于喷他佐辛I组。喷他佐辛II组头晕的发生率高于其他两组。
喷他佐辛可为腰椎间盘突出症患者提供可靠的术后镇痛，与等量舒芬太尼效果相同。与舒芬太尼相比，喷他佐辛不良反应较少。3mg/kg喷他佐辛是术后静脉自控镇痛的最佳剂量。
