Epithelial Sciences Research Group, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK.
Exp Dermatol. 2011 Feb;20(2):88-91. doi: 10.1111/j.1600-0625.2010.01206.x.
Epithelia are found at the interfaces between body compartments where they act as selective permeability barriers that maintain the unique composition of the compartments on either side. Epithelial barrier function is dependent on tight junctions (TJs), which seal the intercellular or paracellular spaces but may permit selective permeability. In simple epithelia (one cell thick), the function of TJs is relatively well understood. By contrast, our understanding of TJ structure and function in stratified epithelia (e.g. the epidermis) is limited. This article briefly discusses what is known about TJs and their components in simple epithelia and speculates about their roles in the epidermis.
上皮组织存在于身体腔室的界面处，它们充当选择性渗透屏障，维持腔室两侧独特的组成。上皮屏障功能依赖于紧密连接（TJ），它封闭细胞间或旁细胞间隙，但可能允许选择性通透性。在简单上皮（一层细胞厚）中，TJ 的功能相对容易理解。相比之下，我们对分层上皮（例如表皮）中 TJ 的结构和功能的理解有限。本文简要讨论了简单上皮中 TJ 及其成分的已知情况，并推测了它们在表皮中的作用。
