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特应性皮炎中的皮肤屏障:超越丝聚蛋白

Skin barrier in atopic dermatitis: beyond filaggrin.

作者信息

Zaniboni Mariana Colombini, Samorano Luciana Paula, Orfali Raquel Leão, Aoki Valéria

机构信息

Universidade de São Paulo (USP) - São Paulo (SP), Brazil.

出版信息

An Bras Dermatol. 2016 Jul-Aug;91(4):472-8. doi: 10.1590/abd1806-4841.20164412.

Abstract

Atopic dermatitis is a chronic inflammatory skin disease with a complex pathogenesis, where changes in skin barrier and imbalance of the immune system are relevant factors. The skin forms a mechanic and immune barrier, regulating water loss from the internal to the external environment, and protecting the individual from external aggressions, such as microorganisms, ultraviolet radiation and physical trauma. Main components of the skin barrier are located in the outer layers of the epidermis (such as filaggrin), the proteins that form the tight junction (TJ) and components of the innate immune system. Recent data involving skin barrier reveal new information regarding its structure and its role in the mechanic-immunological defense; atopic dermatitis (AD) is an example of a disease related to dysfunctions associated with this complex.

摘要

特应性皮炎是一种发病机制复杂的慢性炎症性皮肤病,皮肤屏障改变和免疫系统失衡是相关因素。皮肤形成机械性和免疫屏障,调节从内部到外部环境的水分流失,并保护个体免受外部侵害,如微生物、紫外线辐射和物理创伤。皮肤屏障的主要成分位于表皮外层(如丝聚合蛋白)、形成紧密连接(TJ)的蛋白质以及固有免疫系统的成分。最近有关皮肤屏障的数据揭示了其结构及其在机械免疫防御中的作用的新信息;特应性皮炎(AD)是一种与此复合体功能障碍相关疾病的例子。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0257/4999106/202f5bb8188c/abd-91-04-0472-g01.jpg

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