舌和下唇鳞状细胞癌中基质金属蛋白酶的免疫组织化学表达。
Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip.
机构信息
Department of Pathology and Clinical Dentistry, Federal University of Piauí, Teresina, PI, Brazil.
出版信息
Arch Oral Biol. 2011 Aug;56(8):752-60. doi: 10.1016/j.archoralbio.2010.11.022. Epub 2011 Jan 21.
OBJECTIVE
To evaluate the immunohistochemical expression of MMP-1, -2, -7, -9 and -26 in oral squamous cell carcinomas (SCCs) according to tumour site and histological grade of malignancy.
STUDY DESIGN
Fifteen cases of SCC of the lower lip and 15 cases of tongue SCC were selected and divided into low grade malignancy (n = 17) and high grade malignancy (n = 13).
RESULTS
Higher immunohistochemical expression of MMPs by neoplastic cells was observed in tongue SCCs, with a statistically significant difference for MMP-9 (P < 0.05). High-grade SCCs showed a higher expression of MMPs, except for MMP-2, with a statistically significant difference for MMP-7 (P < 0.05) and MMP-26 (P < 0.05). In addition, a direct association was observed between morphological scores of malignancy and MMP immunoreactivity, with the association being significant for MMP-7 and MMP-26.
CONCLUSION
The present results demonstrate the important role of MMPs in the development of SCCs of the lower lip and tongue.
目的
根据肿瘤部位和组织学恶性程度评估口腔鳞状细胞癌（SCC）中 MMP-1、-2、-7、-9 和 -26 的免疫组织化学表达。
研究设计
选择 15 例下唇 SCC 和 15 例舌 SCC，并将其分为低恶性度（n = 17）和高恶性度（n = 13）两组。
结果
舌 SCC 中肿瘤细胞 MMP 的免疫组织化学表达较高，其中 MMP-9 的差异具有统计学意义（P < 0.05）。高恶性 SCC 组 MMP 的表达较高，除 MMP-2 外，差异均具有统计学意义（P < 0.05），MMP-7 和 MMP-26 的差异具有显著统计学意义（P < 0.05）。此外，恶性形态评分与 MMP 免疫反应之间存在直接关联，其中 MMP-7 和 MMP-26 的关联具有显著统计学意义。
结论
本研究结果表明 MMP 在唇和舌 SCC 的发生发展中具有重要作用。
Zotero 插件