发育过程中同源结构域蛋白核转运中的核转运蛋白
Karyopherins in nuclear transport of homeodomain proteins during development.
作者信息
Ye Wenduo, Lin Wenbo, Tartakoff Alan M, Tao Tao
机构信息
Xiamen University School of Life Sciences, Xiamen, Fujian 361005, China.
出版信息
Biochim Biophys Acta. 2011 Sep;1813(9):1654-62. doi: 10.1016/j.bbamcr.2011.01.013. Epub 2011 Jan 20.
Abstract
Homeodomain proteins are crucial transcription factors for cell differentiation, cell proliferation and organ development. Interestingly, their homeodomain signature structure is important for both their DNA-binding and their nucleocytoplasmic trafficking. The accurate nucleocytoplasmic distribution of these proteins is essential for their functions. We summarize information on (a) the roles of karyopherins for import and export of homeoproteins, (b) the regulation of their nuclear transport during development, and (c) the corresponding complexity of homeoprotein nucleocytoplasmic transport signals. This article is part of a Special Issue entitled: Regulation of Signaling and Cellular Fate through Modulation of Nuclear Protein Import.
摘要
同源域蛋白是细胞分化、细胞增殖和器官发育过程中至关重要的转录因子。有趣的是，它们的同源域特征结构对于其DNA结合以及核质运输都很重要。这些蛋白在核质中的准确分布对其功能至关重要。我们总结了以下方面的信息：（a）核转运蛋白在同源蛋白进出核过程中的作用；（b）发育过程中它们核运输的调控；（c）同源蛋白核质运输信号相应的复杂性。本文是名为：通过调节核蛋白输入来调控信号传导和细胞命运 的特刊的一部分。
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