mRNA 从细胞核输出：一系列分子换装。
Messenger RNA export from the nucleus: a series of molecular wardrobe changes.
机构信息
Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA.
出版信息
Traffic. 2009 Sep;10(9):1199-208. doi: 10.1111/j.1600-0854.2009.00944.x. Epub 2009 Jun 27.
Abstract
The advent of the nucleus during the evolutionary development of the eukaryotic cell necessitated the development of a transport system to convey messenger RNA (mRNA) from the site of transcription in the nucleus to ribosomes in the cytoplasm. In this review, we highlight components of each step in mRNA biogenesis, from transcription to processing, that are coupled with mRNA export from the nucleus. We also review the mechanism by which proteins from one step in the mRNA assembly line are replaced by those required for the next. These 'molecular wardrobe changes' appear to be key steps in facilitating the rapid and efficient nuclear export of mRNA transcripts.
摘要
在真核细胞的进化发展过程中，核的出现使得需要开发一种运输系统，将信使 RNA（mRNA）从核转录部位输送到细胞质中的核糖体。在这篇综述中，我们强调了 mRNA 生物发生过程中从转录到加工的每个步骤的组成部分，这些步骤与 mRNA 从核内输出耦联。我们还回顾了在 mRNA 装配线上的一个步骤中，蛋白质被下一个步骤所需的蛋白质取代的机制。这些“分子衣橱变化”似乎是促进 mRNA 转录本快速高效核输出的关键步骤。
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