University Lille Nord de France, F-59000 Lille, France.
Int J Pharm. 2011 Sep 30;417(1-2):17-31. doi: 10.1016/j.ijpharm.2011.01.031. Epub 2011 Jan 21.
We show in this paper the contribution of the whole Raman spectrum including the phonon spectrum, to detect, identify and characterize polymorphic forms of molecular compounds, and study their stability and transformation. Obtaining these kinds of information is important in the area of pharmaceutical compounds. Two different polymorphic systems are analyzed through investigations in indomethacin and caffeine exposed to variable environmental conditions and various stresses, as possibly throughout the production cycle of the active pharmaceutical ingredient. It is shown the capability of the low-frequency Raman spectroscopy to reveal disorder in the crystalline state, to detect small amorphous or crystalline material, and to elucidate ambiguous polymorphic or polyamorphic situations.
本文展示了整个拉曼光谱（包括声子谱）在检测、识别和表征分子化合物的多晶型形式，以及研究其稳定性和转化方面的贡献。在药物化合物领域，获取这些信息非常重要。通过对吲哚美辛和咖啡因在不同环境条件和各种应力下的研究，分析了两种不同的多晶型系统，这些条件可能贯穿于活性药物成分的整个生产周期。本文还展示了低频拉曼光谱在揭示晶体态无序、检测小的非晶或结晶物质以及阐明多晶型或多晶型情况方面的能力。
