Veterinary Teaching Hospital, College of Sciences, Massey University, Palmerston North, New Zealand.
Vet Rec. 2011 Jan 8;168(1):19. doi: 10.1136/vr.c5992. Epub 2010 Dec 17.
The aim of this study was to investigate the use of a gonadotrophin-releasing hormone (GnRH) vaccine in the treatment of headshaking in horses. Fifteen geldings received two doses of the GnRH vaccine four weeks apart. Serum was collected before and after vaccination to measure concentrations of luteinising hormone (LH) (10 horses) and follicle-stimulating hormone (FSH) (six horses). Owners recorded the frequency of seven common headshaking behaviours using a visual analogue scale (VAS) before vaccination and at two, four, eight, 12, 16 and 20 weeks after vaccination. Serum LH (P=0.008) and FSH (P=0.03) concentrations decreased significantly following vaccination. Although approximately one-third of the owners reported a subjective improvement in headshaking, serial scoring did not indicate a reduction in headshaking behaviours following vaccination with a commercial GnRH vaccine. Vaccination reactions were observed in four of 15 horses (27 per cent), including one case of severe, presumed immune-mediated, myositis.
本研究旨在探讨促性腺激素释放激素（GnRH）疫苗在马摇头（headshaking）治疗中的应用。15 匹去势公马间隔四周接受两剂 GnRH 疫苗。在接种前后采集血清，以测量促黄体激素（LH）（10 匹马）和促卵泡激素（FSH）（6 匹马）的浓度。在接种前和接种后 2、4、8、12、16 和 20 周，所有者使用视觉模拟量表（VAS）记录了 7 种常见摇头行为的频率。接种后，血清 LH（P=0.008）和 FSH（P=0.03）浓度显著下降。尽管约三分之一的马主报告主观上摇头症状有所改善，但连续评分并未表明接种商业 GnRH 疫苗后摇头行为减少。在 15 匹马中观察到 4 例（27%）接种反应，包括 1 例严重的、疑似免疫介导的肌炎。
