Sheldon Shara A, Aleman Monica, Costa Lais R R, Weich Kalie, Howey Quinn, Madigan John E
Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California.
J Vet Intern Med. 2019 May;33(3):1464-1472. doi: 10.1111/jvim.15499. Epub 2019 Apr 16.
Oral administration of magnesium and boron might have a beneficial effect on headshaking behavior in horses.
Evaluate the effects of oral magnesium alone or in combination with boron on headshaking behavior in affected horses.
Twelve geldings (6 healthy controls and 6 affected).
Prospective randomized controlled dietary trial over 42 days in 12 horses (6 horses diagnosed with trigeminal-mediated headshaking and 6 unaffected healthy controls). All horses received a hay diet and were randomized into 3 treatment groups: pelleted feed combination (PF), pelleted feed combination with magnesium (M), and pelleted feed combination with magnesium-boron (MB) with a week washout of hay only between treatments. Headshaking behavior and biochemical blood variables were assessed at baseline (hay only) and then after each week of supplementation.
All 3 diet interventions increased blood ionized and total magnesium. Groups M and MB further increased Mg when compared to PF. Horses receiving treatments had a significant reduction in headshaking behavior, as measured by incidence rate ratio (IRR), when compared to unsupplemented hay diet (44% for PF, IRR, 0.558; CI, 0.44, 0.72; P < .001; 52% for M, IRR, 0.476; CI, 0.37, 0.62; P < .001; and 64% for MB, IRR, 0.358; CI, 0.27, 0.48; P < .001).
Magnesium in combination with boron had the greatest decrease in headshaking. Oral supplementation with magnesium or magnesium in combination with boron should be considered in horses affected with headshaking.
口服镁和硼可能对马匹的摇头行为产生有益影响。
评估单独口服镁或镁与硼联合使用对患马摇头行为的影响。
12匹雄性马（6匹健康对照和6匹患病马）。
对12匹马（6匹被诊断为三叉神经介导的摇头症的马和6匹未受影响的健康对照）进行为期42天的前瞻性随机对照饮食试验。所有马匹均以干草为食，并随机分为3个治疗组：颗粒饲料组合（PF）、含镁颗粒饲料组合（M）和含镁硼颗粒饲料组合（MB），治疗之间仅用一周时间清洗干草。在基线期（仅喂干草）以及每次补充后的每周评估摇头行为和血液生化指标。
所有3种饮食干预均提高了血液中的离子镁和总镁含量。与PF组相比，M组和MB组的镁含量进一步升高。与未补充干草饮食相比，接受治疗的马匹的摇头行为通过发病率比（IRR）测量有显著降低（PF组降低44%，IRR为0.558；CI为0.44, 0.72；P <.001；M组降低52%，IRR为0.476；CI为0.37, 0.62；P <.001；MB组降低64%，IRR为0.358；CI为0.27, 0.48；P <.001）。
镁与硼联合使用时摇头行为减少最多。对于患有摇头症的马匹，应考虑口服补充镁或镁与硼的组合。
