Unità Operativa di Reumatologia, Hospital S. Maria Nuova, Reggio Emilia, Italy.
Rheumatology (Oxford). 2011 Jun;50(6):1025-32. doi: 10.1093/rheumatology/keq416. Epub 2011 Jan 21.
Chronic periaortitis (CP) is a rare disease characterized by a fibro-inflammatory tissue surrounding the abdominal aorta, and includes non-aneurysmal [idiopathic retroperitoneal fibrosis (IRF)] and aneurysmal forms [inflammatory abdominal aortic aneurysm (IAAA)]. We investigated whether CC chemokine receptor 5 (CCR5)Δ32 polymorphism confers susceptibility to CP.
One hundred CP patients and 180 healthy controls were genotyped for CCR5Δ32 polymorphism by molecular methods. The patients were subgrouped according to the type of CP (IRF or IAAA) and the presence of established atherosclerotic disease (ischaemic heart disease, cerebrovascular disease and peripheral arterial disease).
The distribution of the CCR5Δ32 genotype differed between CP patients and controls (P = 0.01). The CCR5Δ32 allele was more frequent in CP patients than in controls [P = 0.02, odds ratio (OR) 2.8 (95% CI 1.2, 6.4)]. The distribution of the CCR5Δ32 genotype did not differ significantly between IRF patients and controls, whereas the CCR5Δ32 allele was more frequent in IAAA patients than in controls [P = 0.0001, OR 10.0 (95% CI 3.7, 27.3)]. Furthermore, the CCR5Δ32 allele occurred more frequently in IAAA than in IRF patients [P = 0.001, OR 6.4 (95% CI 2.1, 19.1)]. The CCR5Δ32 allele frequency was higher in IAAA patients without established atherosclerotic disease compared with controls [66.7 vs 5.6%, P = 0.00001, OR 34.0 (95% CI 7.4, 156.3)], but not in IAAA patients with atherosclerotic disease and IRF patients with or without atherosclerotic disease.
The CCR5Δ32 polymorphism might be associated with an increased risk of developing the aneurysmal form of CP, IAAA, particularly in patients without established atherosclerotic disease. Chemokines may have a role in the pathophysiology of CP.
慢性大动脉炎（CP）是一种罕见的疾病，其特征为纤维炎症组织围绕腹主动脉，包括非动脉瘤性（特发性腹膜后纤维化（IRF））和动脉瘤性形式（炎症性腹主动脉瘤（IAAA））。我们研究了 C 趋化因子受体 5（CCR5）Δ32 多态性是否与 CP 易感性相关。
采用分子方法对 100 例 CP 患者和 180 例健康对照者进行 CCR5Δ32 多态性基因分型。根据 CP 类型（IRF 或 IAAA）和是否存在已确立的动脉粥样硬化疾病（缺血性心脏病、脑血管病和外周动脉疾病）对患者进行亚组分类。
CP 患者和对照组之间 CCR5Δ32 基因型的分布不同（P=0.01）。CP 患者的 CCR5Δ32 等位基因比对照组更频繁[P=0.02，比值比（OR）2.8（95%CI 1.2，6.4）]。IRF 患者与对照组之间 CCR5Δ32 基因型的分布无显著差异，而 IAAA 患者的 CCR5Δ32 等位基因比对照组更频繁[P=0.0001，OR 10.0（95%CI 3.7，27.3）]。此外，IAAA 患者的 CCR5Δ32 等位基因比 IRF 患者更频繁[P=0.001，OR 6.4（95%CI 2.1，19.1）]。与对照组相比，无已确立动脉粥样硬化疾病的 IAAA 患者的 CCR5Δ32 等位基因频率更高[66.7%比 5.6%，P=0.00001，OR 34.0（95%CI 7.4，156.3）]，但在有动脉粥样硬化疾病的 IAAA 患者和有或无动脉粥样硬化疾病的 IRF 患者中并非如此。
CCR5Δ32 多态性可能与发展 CP 的动脉瘤性形式、IAAA 的风险增加相关，尤其是在无已确立动脉粥样硬化疾病的患者中。趋化因子可能在 CP 的病理生理学中起作用。
