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[卡他布兰汉菌:其在儿童期的呼吸道致病性]

[Branhamella catarrhalis: its respiratory pathogenicity in childhood].

作者信息

Moreno Galdo A, Ferrer Marcelles A, Aizpurúa Galdeano P, Navarro Aguirre M, Fernández Pérez F, Iglesias Berengue J

机构信息

Servicio de Pediatría, Ciudad Sanitaria Valle de Hebrón Barcelona.

出版信息

An Esp Pediatr. 1990 Aug;33(2):135-9.

PMID:2125809
Abstract

Branhamella catarrhalis is a nasopharyngeal commensal which is being increasingly recognised as a pathogen, causing mainly infective exacerbations of chronic lung disease. It can also originate serious infections, like septicaemia, in patients with chronic predisposing conditions. During the period from 1979 to 1987, 22,501 respiratory tract samples from children were evaluated. Ninety nine isolated of Branhamella catarrhalis were identified (0.44%). Patients' age extended from 12 days to 9 years, with patients younger than two years representing 73%. Sixty three out of 77 cases investigated (82%) were positive for beta-lactamase. The most frequent finding was the recovery of Branhamella catarrhalis in tracheal aspirates from children with a tracheotomy or prolonged nasotracheal intubation. One of these children had a septic episode during which Branhamella catarrhalis was isolated from blood. Also remarkable is a case of pneumonia in a patient with congenital hypogammaglobulinaemia. Branhamella catarrhalis was also recovered in a wide variety of acute upper and lower respiratory tract infections in children without previous predisposing conditions. It is less clear its pathogenic role in these cases.

摘要

卡他布兰汉菌是一种鼻咽部共生菌,如今越来越被视为一种病原体,主要引起慢性肺部疾病的感染性加重。它也可在有慢性易感因素的患者中引发严重感染,如败血症。在1979年至1987年期间,对来自儿童的22501份呼吸道样本进行了评估。共鉴定出99株卡他布兰汉菌(0.44%)。患者年龄从12天至9岁不等,其中两岁以下患者占73%。在77例受调查病例中,有63例(82%)β-内酰胺酶检测呈阳性。最常见的情况是在接受气管切开术或长期鼻气管插管的儿童的气管吸出物中发现卡他布兰汉菌。其中一名儿童发生了败血症,期间从血液中分离出了卡他布兰汉菌。同样值得注意的是一名先天性低丙种球蛋白血症患者发生的肺炎病例。在没有先前易感因素的儿童的各种急性上呼吸道和下呼吸道感染中也发现了卡他布兰汉菌。在这些病例中其致病作用尚不太明确。

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