ADAM10 与胃癌的进展和患者预后相关。

ADAM 10 is associated with gastric cancer progression and prognosis of patients.

机构信息

Wenzhou Medical College, Wenzhou, Zhejiang, PR China.

出版信息

J Surg Oncol. 2011 Feb;103(2):116-23. doi: 10.1002/jso.21781. Epub 2010 Nov 23.

DOI:10.1002/jso.21781

PMID:21259244

Abstract

BACKGROUND

The metalloproteinase domain-containing protein 10 (ADAM 10) has been implicated in the development and progression of gastric cancer.

METHODS

Expression of ADAM 10 and C-erbB-2 were examined immunochemically in 436 clinicopathologically characterized gastric cancer cases.

RESULTS

Protein levels of ADAM 10 and C-erbB-2 were up-regulated in gastric cancer lesions compared with adjacent non-cancerous tissues. Positive expression of ADAM 10 correlated with age, size of tumor, location of tumor, depth of invasion, vessel invasion, lymph node, and distant metastasis and TNM stage, and also with expression of C-erbB-2. In stages I, II, and III, the 5-year survival rate of patients with high ADAM 10 expression was significantly lower than in patients with low expression. However, in stage IV, ADAM 10 expression did not correlate with the 5-year survival rate. Further multivariate analysis suggests that up-regulation of ADAM 10 and C-erbB-2 were independent prognostic indicators for the disease, along with depth of invasion, lymph node and distant metastasis and TNM stage.

CONCLUSION

Expression of ADAM 10 in gastric cancer is significantly associated with lymph node and distant metastasis, high C-erbB-2 expression, and poor prognosis. ADAM 10 and C-erbB-2 proteins could be useful markers to predict tumor progression and prognosis.

摘要

背景

金属蛋白酶结构域蛋白 10（ADAM10）已被牵涉到胃癌的发展和进展中。

方法

采用免疫组织化学方法检测 436 例临床病理特征明确的胃癌病例中 ADAM10 和 C-erbB-2 的表达情况。

结果

与相邻非癌组织相比，胃癌病变中 ADAM10 和 C-erbB-2 的蛋白水平上调。ADAM10 的阳性表达与年龄、肿瘤大小、肿瘤位置、浸润深度、血管浸润、淋巴结和远处转移以及 TNM 分期有关，也与 C-erbB-2 的表达有关。在 I、II 和 III 期，高表达 ADAM10 的患者 5 年生存率明显低于低表达患者。然而，在 IV 期，ADAM10 的表达与 5 年生存率无关。进一步的多因素分析表明，ADAM10 和 C-erbB-2 的上调是疾病的独立预后指标，与浸润深度、淋巴结和远处转移以及 TNM 分期有关。